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    NEXT-GENERATION DNA SEQUENCING INFORMATICS
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    779577

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    Sinopse

    Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applications including variant (mutation) discovery, gene expression, transcription factor analysis, metagenomics, and epigenetics. Bioinformatics methods to support DNA sequencing have become and remain a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. This new edition provides a thorough, plain-language introduction to the necessary informatics methods and tools for analyzing NGS data and provides detailed descriptions of algorithms, strengths and weaknesses of specific tools, pitfalls, and alternative methods. Four new chapters cover experimental design, sample preparation, and quality assessment of NGS data; public databases for DNA sequencing data; de novo transcript assembly; proteogenomics; and emerging sequencing technologies. The remaining chapters from the first edition have been updated with the latest information. This book also provides extensive reference to best-practice bioinformatics methods for NGS applications and tutorials for common workflows. This edition addresses the informatics needs of students, laboratory scientists, and computing specialists who wish to take advantage of the explosion of research opportunities offered by new DNA sequencing technologies.
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    ISBN9781621821236
    Peso449g
    Livro disponível - pronta entregaNão
    IdiomaInglês
    Tipo itemLivro Importado
    Número de páginas402
    Número da edição2ª EDIÇÃO - 2015
    Código Interno779577
    Código de barras9781621821236
    AcabamentoHARDCOVER
    EditoraCOLD SPRING HARBOR LABORATORY PRESS
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